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The purpose of this study is to examine the effects of organic and inorganic fertilizers on the growth and quality of peppermint (Mentha piperita). The field experiment was carried out in randomized complete block design with 3 treatments and 4 replicates in the Federal University of Agriculture, Abeokuta in 2017. Treatments were: 1- control, 2- sunshine organic fertilizer, 3- urea. Peppermint vine cuttings of 10cm were planted into 12 tilled beds (8m2) with Sunshine organic fertilizer applied two weeks before planting on four beds and Urea applied two weeks after planting on four beds and four beds devoid of any fertilizer application. The result showed that the Application of Sunshine organic fertilizer and Urea significantly enhanced vegetative growth parameters. The effect was maximal with the application of Sunshine organic fertilizer with respect to the number of leaves, the number of tendrils, fresh weight, and dry weight as compared with the application of Urea and Control. The result also showed that Control produced better proximate content as compared with the application of Sunshine organic fertilizer and Urea. However, the application of Urea and Control produced better mineral content as compared with the application of Sunshine organic fertilizer. Application of Sunshine organic fertilizer produced better phytochemical content in the peppermint leaves as compared with the application of Urea and Control. The effect was maximal with the application of Sunshine organic fertilizer with respect to Tannin, Flavonoids, and Saponin as compared with the application of Urea and Control.