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Wheat is the most important cereal crop in the world that ranks first position in terms of production and trade. In Nepal this is the third most cultivated crop after rice and maize. Various environmental constraints including heat stress have been determined to be a great factor to limit world wheat production. High temperature leaves a devastating impact in wheat production by affecting different stages including germination, plant growth, anthesis and grain filling etc. heat stress also affects photosynthesis process and responsible for the lower biomass yield. Various studies have shown that the reproductive stages of wheat plant are more susceptible to heat stress than vegetative stages. Heat stress hinders germination, reduce plant growth, decrease number of plant population per unit area and causes leaf senescence. Water relation disturbance and oxidative damage to plants are other harmful effects of heat stress in wheat plants. Plant also has tolerance mechanism against such heat induced stresses. Such mechanisms include avoidance against heat stress, production of heat shock protein and antioxidant mechanisms.